About the research:
Alzheimer’s disease (AD) is a neurodegenerative condition pathologically characterized by the accumulation of amyloid aggregates in the brain. In this project, we propose the transplant of proteasomes — subcellular complexes essential for the degradation of damaged and misfolded proteins — as a strategy to clear protein aggregates in the brains of AD mice. This way, we will evaluate whether proteasome transplantation can recover amyloid pathology, neuroinflammation, synapses, and memory in AD experimental models. This project tests a new therapeutic approach for AD that, if successful, establishes potential for other neurodegenerative diseases.
Selected publications:
Ribeiro, F. C., Cozachenco, D., Heimfarth, L., Fortuna, J. T. S., de Freitas, G. B., de Sousa, J. M., Alves-Leon, S. V., Leite, R. E. P., Suemoto, C. K., Grinberg, L. T., De Felice, F. G., Lourenco, M. V., & Ferreira, S. T. (2023). Synaptic proteasome is inhibited in Alzheimer’s disease models and associates with memory impairment in mice. Communications biology, 6(1), 1127. https://doi.org/10.1038/s42003-023-05511-9
Cozachenco, D., Ribeiro, F. C., & Ferreira, S. T. (2023). Defective proteostasis in Alzheimer’s disease. Ageing research reviews, 85, 101862. https://doi.org/10.1016/j.arr.2023.101862
