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Patrícia Santana

Sobre

Researcher with more than 15 years of experience in immunology and inflammatory diseases, with a PhD in Biological Sciences. She is currently a visiting researcher at the Innovative Genomics Institute (IGI) at UC Berkeley as a Pioneer Science fellow, investigating the interaction between the microbiome and immunogenomics in inflammatory bowel diseases such as Crohn’s and ulcerative colitis. She uses 2D and 3D stem-cell-derived cell models, animal models, and genomic approaches to understand the immunological mechanisms driving chronic inflammation and immune-system dysfunction.

Áreas de Pesquisa:

Cellular and Molecular Biology

About the research:

She leads innovative projects on host–microbiome interactions in inflammatory bowel disease (IBD). In the first project, she characterizes stool samples from patients with ulcerative colitis, Crohn’s disease, and controls using intestinal organoids and immune models, validating fluorescent reporters for AhR and NFκB and analyzing transcriptional responses via RNAseq. In the second, she studies the effect of AhR activation in the intestinal epithelium under inflammation and chemotherapy, identifying contexts in which agonists such as Tapinarof protect cells. She also develops organoid/macrophage and organoid/bacteria co-culture systems, has analyzed human microbiomes, and has initiated IBD murine models, strengthening experimental platforms to investigate inflammation and response.

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