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Corynne Adanho

Sobre

Researcher in gene therapy and molecular biology. She holds a PhD in Human and Experimental Pathology from UFBA, in partnership with FIOCRUZ, a master’s in Biochemistry from the Université d’Abomey-Calavi (Benin), and a specialization in Epidemiology Applied to SUS Services from Fiocruz. Her scientific career has evolved from studying severe anemia in malaria to the identification of stroke risk biomarkers in patients with sickle cell anemia. She is currently developing CRISPR-based gene-editing strategies, focusing on the reactivation of fetal hemoglobin in hematopoietic stem cells for the treatment of hemoglobinopathies. She has also worked with induced pluripotent stem cells.

Áreas de Pesquisa:

Cellular and Molecular Biology

About the research:

Sickle cell anemia (SCA) is a major global health challenge, with curative options still limited and hard to access. Although CRISPR-based therapies targeting BCL11A to reactivate fetal hemoglobin (HbF) have shown promising results, current ex vivo approaches remain costly and difficult to implement at scale. My work consists of optimizing a peptide-mediated non-viral CRISPR delivery platform (PERC) for the efficient editing of hematopoietic stem and progenitor cells, aiming to induce HbF production. The goal is to enable the translation of this strategy into a clinical trial in Brazil, broadening access.

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