Molecular biologist and virologist by training, with a bachelor’s, master’s, and PhD in Genetics (UFRJ), and postdoctoral research at UFMG and Stanford University. He is currently a researcher and PI of the Pioneer Science initiative (IDOR-SP).
Molecular biologist and virologist by training, with a bachelor’s, master’s, and PhD in Genetics (UFRJ), and postdoctoral research at UFMG and Stanford University. He is currently a researcher and PI of the Pioneer Science initiative (IDOR-SP).
Arthritogenic alphaviruses such as Chikungunya and Mayaro, in addition to the characteristic symptoms of the acute phase, can cause chronic arthralgia, mainly in the wrists, knees, and ankles. This outcome of chronic joint inflammation leads to morbidity that can persist from weeks to years. In immunocompetent mouse models that reproduce the transition from the acute to the chronic phase of CHIKV and MAYV infections, as well as their inflammatory response, it is possible to detect viral RNA in muscle tissues of the mice in the chronic phase, even though viral-particle production is no longer detectable. To clarify this phenomenon, the project investigates the molecular mechanisms of the immune response, as well as RNA regulation and the role of potential viral persistence in sustaining the chronic inflammatory state.
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